Liposomal Apigenin is a new-type preparation that encapsulates apigenin in liposomes. Here is a detailed introduction to it:
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Properties and limitations of apigenin: Apigenin is a natural flavonoid widely found in various plants such as chamomile, onions, and celery. It has multiple biological activities including antioxidant, anti-inflammatory, anti-tumor, and neuroprotective effects. However, due to its poor water solubility, it is easily degraded in the gastrointestinal tract, resulting in low bioavailability, which limits its clinical application.
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Function of liposomes: Liposomes are mainly composed of a hydrophilic compartment and a lipid bilayer. They can encapsulate hydrophobic apigenin in the interlayer or core of the bilayer structure, improving its water solubility and enhancing the stability of the drug. At the same time, liposomes have advantages such as high drug-loading efficiency, high stability in the biological environment, certain sustained-release effect, cell affinity, and targeting property. These advantages enable apigenin to reach the target site more accurately, prolong its action time, thereby improving its bioavailability and efficacy.
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Advantages of NF Lipo®Liposomal Apigenin:
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Encapsulating apigenin with liposomes can protect it from the damage of digestive enzymes, allowing it to pass through the gastrointestinal tract more effectively and enter the blood circulation. After entering the blood, liposomes can release apigenin gradually, with the release time reaching 24 hours, achieving long-acting sustained release and maximizing the active effect of apigenin.
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Application fields: In the pharmaceutical field, Liposomal Apigenin can be used to prepare drugs for anti-inflammatory skin diseases, such as drugs for allergic dermatitis. Studies have also found that it has the effect of enhancing the chemotherapy effect on tumor cells such as colorectal cancer. In the health care field, it can be used as a dietary supplement for enhancing cognition, reducing stress, promoting cell health, and delaying aging, etc.
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